Nucleotide sequence of the avian influenza A/Mallard/NY/6750/78 virus polymerase genes
Identifieur interne : 002150 ( Main/Exploration ); précédent : 002149; suivant : 002151Nucleotide sequence of the avian influenza A/Mallard/NY/6750/78 virus polymerase genes
Auteurs : John Treanor ; Kawaoka Yoshihiro [États-Unis] ; Roger Miller ; Robert G. Webster [États-Unis] ; Brian MurphySource :
- Virus Research [ 0168-1702 ] ; 1989.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : DNA, Viral, RNA-Directed DNA Polymerase.
- enzymology : Influenza A virus.
- genetics : Influenza A virus.
- Teeft :
- Amino, Amino Acid Sequence, Amino acid sequence, Amino acid sequences, Amino acids, Animal influenza, Animals, Attenuated, Avian, Avian influenza, Avian influenza virus, Avian virus, Base Sequence, Embryonated eggs, Encoding, Gene, Gene segment, Gene segments, Genes, Viral, Hlnl, Homology, Human influenza, Human influenza virus, Human virus, Human viruses, Humans, Influenza, Influenza virus, Internal genes, Location signals, Molecular Sequence Data, Nuclear location signal, Nucleoprotein, Nucleotide, Nucleotide sequence, Nucleotide sequences, Polymerase, Polymerase gene segments, Polymerase genes, Polymerase proteins, Reassortant, Reassortant virus, Reassortant viruses, Replication, Sequence Homology, Nucleic Acid, Sequencing, Squirrel monkeys, Vaccine, Virology, Virus.
Abstract
Abstract: The avian influenza A/Mallard/NY/6750/78 virus is currently being evaluated as a donor of attenuating genes in the construction of live avian-human influenza A reassortant virus vaccines for use in humans. We determined the nucleotide sequences of the three polymerase gene segments of this virus. This completes the nucleotide sequence of the six transferrable genes of the avian donor virus. Comparison of the nucleotide and deduced amino acid sequences of the non-glycoprotein genes of the avian A/Mallard/78 virus with representative avian and human influenza A viruses suggests that the PB1 gene of H2N2 subtype human influenza A viruses may have been derived from a non-human, possibly avian influenza A virus by genetic reassortment. In addition, several regions of conserved amino acids with potential functional significance were identified in the deduced amino acid sequences of the polymerase proteins.
Url:
DOI: 10.1016/0168-1702(89)90006-3
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000189
- to stream Istex, to step Curation: 000189
- to stream Istex, to step Checkpoint: 000E71
- to stream PubMed, to step Corpus: 000461
- to stream PubMed, to step Curation: 000461
- to stream PubMed, to step Checkpoint: 000411
- to stream Ncbi, to step Merge: 000A46
- to stream Ncbi, to step Curation: 000A46
- to stream Ncbi, to step Checkpoint: 000A46
- to stream Main, to step Merge: 002254
- to stream Main, to step Curation: 002150
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Nucleotide sequence of the avian influenza A/Mallard/NY/6750/78 virus polymerase genes</title>
<author><name sortKey="Treanor, John" sort="Treanor, John" uniqKey="Treanor J" first="John" last="Treanor">John Treanor</name>
</author>
<author><name sortKey="Yoshihiro, Kawaoka" sort="Yoshihiro, Kawaoka" uniqKey="Yoshihiro K" first="Kawaoka" last="Yoshihiro">Kawaoka Yoshihiro</name>
</author>
<author><name sortKey="Miller, Roger" sort="Miller, Roger" uniqKey="Miller R" first="Roger" last="Miller">Roger Miller</name>
</author>
<author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name>
</author>
<author><name sortKey="Murphy, Brian" sort="Murphy, Brian" uniqKey="Murphy B" first="Brian" last="Murphy">Brian Murphy</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:5174CC987A39013BB6ADFFBCD08CABDFC01216C1</idno>
<date when="1989" year="1989">1989</date>
<idno type="doi">10.1016/0168-1702(89)90006-3</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-VVKR89MJ-M/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000189</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000189</idno>
<idno type="wicri:Area/Istex/Curation">000189</idno>
<idno type="wicri:Area/Istex/Checkpoint">000E71</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000E71</idno>
<idno type="wicri:doubleKey">0168-1702:1989:Treanor J:nucleotide:sequence:of</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:2483012</idno>
<idno type="wicri:Area/PubMed/Corpus">000461</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000461</idno>
<idno type="wicri:Area/PubMed/Curation">000461</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000461</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000411</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000411</idno>
<idno type="wicri:Area/Ncbi/Merge">000A46</idno>
<idno type="wicri:Area/Ncbi/Curation">000A46</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000A46</idno>
<idno type="wicri:doubleKey">0168-1702:1989:Treanor J:nucleotide:sequence:of</idno>
<idno type="wicri:Area/Main/Merge">002254</idno>
<idno type="wicri:Area/Main/Curation">002150</idno>
<idno type="wicri:Area/Main/Exploration">002150</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Nucleotide sequence of the avian influenza A/Mallard/NY/6750/78 virus polymerase genes</title>
<author><name sortKey="Treanor, John" sort="Treanor, John" uniqKey="Treanor J" first="John" last="Treanor">John Treanor</name>
<affiliation><wicri:noCountry code="subField">MarylandUSA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yoshihiro, Kawaoka" sort="Yoshihiro, Kawaoka" uniqKey="Yoshihiro K" first="Kawaoka" last="Yoshihiro">Kawaoka Yoshihiro</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis</wicri:regionArea>
<wicri:noRegion>Memphis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miller, Roger" sort="Miller, Roger" uniqKey="Miller R" first="Roger" last="Miller">Roger Miller</name>
<affiliation><wicri:noCountry code="subField">MarylandUSA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis</wicri:regionArea>
<wicri:noRegion>Memphis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Murphy, Brian" sort="Murphy, Brian" uniqKey="Murphy B" first="Brian" last="Murphy">Brian Murphy</name>
<affiliation><wicri:noCountry code="subField">MarylandUSA</wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Virus Research</title>
<title level="j" type="abbrev">VIRUS</title>
<idno type="ISSN">0168-1702</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1989">1989</date>
<biblScope unit="volume">14</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="257">257</biblScope>
<biblScope unit="page" to="269">269</biblScope>
</imprint>
<idno type="ISSN">0168-1702</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0168-1702</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>DNA, Viral (genetics)</term>
<term>Genes, Viral</term>
<term>Humans</term>
<term>Influenza A virus (enzymology)</term>
<term>Influenza A virus (genetics)</term>
<term>Molecular Sequence Data</term>
<term>RNA-Directed DNA Polymerase (genetics)</term>
<term>Sequence Homology, Nucleic Acid</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral (génétique)</term>
<term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Gènes viraux</term>
<term>Humains</term>
<term>RNA-directed DNA polymerase (génétique)</term>
<term>Similitude de séquences d'acides nucléiques</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Virus de la grippe A (enzymologie)</term>
<term>Virus de la grippe A (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Viral</term>
<term>RNA-Directed DNA Polymerase</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN viral</term>
<term>RNA-directed DNA polymerase</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Amino</term>
<term>Amino Acid Sequence</term>
<term>Amino acid sequence</term>
<term>Amino acid sequences</term>
<term>Amino acids</term>
<term>Animal influenza</term>
<term>Animals</term>
<term>Attenuated</term>
<term>Avian</term>
<term>Avian influenza</term>
<term>Avian influenza virus</term>
<term>Avian virus</term>
<term>Base Sequence</term>
<term>Embryonated eggs</term>
<term>Encoding</term>
<term>Gene</term>
<term>Gene segment</term>
<term>Gene segments</term>
<term>Genes, Viral</term>
<term>Hlnl</term>
<term>Homology</term>
<term>Human influenza</term>
<term>Human influenza virus</term>
<term>Human virus</term>
<term>Human viruses</term>
<term>Humans</term>
<term>Influenza</term>
<term>Influenza virus</term>
<term>Internal genes</term>
<term>Location signals</term>
<term>Molecular Sequence Data</term>
<term>Nuclear location signal</term>
<term>Nucleoprotein</term>
<term>Nucleotide</term>
<term>Nucleotide sequence</term>
<term>Nucleotide sequences</term>
<term>Polymerase</term>
<term>Polymerase gene segments</term>
<term>Polymerase genes</term>
<term>Polymerase proteins</term>
<term>Reassortant</term>
<term>Reassortant virus</term>
<term>Reassortant viruses</term>
<term>Replication</term>
<term>Sequence Homology, Nucleic Acid</term>
<term>Sequencing</term>
<term>Squirrel monkeys</term>
<term>Vaccine</term>
<term>Virology</term>
<term>Virus</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Gènes viraux</term>
<term>Humains</term>
<term>Similitude de séquences d'acides nucléiques</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: The avian influenza A/Mallard/NY/6750/78 virus is currently being evaluated as a donor of attenuating genes in the construction of live avian-human influenza A reassortant virus vaccines for use in humans. We determined the nucleotide sequences of the three polymerase gene segments of this virus. This completes the nucleotide sequence of the six transferrable genes of the avian donor virus. Comparison of the nucleotide and deduced amino acid sequences of the non-glycoprotein genes of the avian A/Mallard/78 virus with representative avian and human influenza A viruses suggests that the PB1 gene of H2N2 subtype human influenza A viruses may have been derived from a non-human, possibly avian influenza A virus by genetic reassortment. In addition, several regions of conserved amino acids with potential functional significance were identified in the deduced amino acid sequences of the polymerase proteins.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><noCountry><name sortKey="Miller, Roger" sort="Miller, Roger" uniqKey="Miller R" first="Roger" last="Miller">Roger Miller</name>
<name sortKey="Murphy, Brian" sort="Murphy, Brian" uniqKey="Murphy B" first="Brian" last="Murphy">Brian Murphy</name>
<name sortKey="Treanor, John" sort="Treanor, John" uniqKey="Treanor J" first="John" last="Treanor">John Treanor</name>
</noCountry>
<country name="États-Unis"><noRegion><name sortKey="Yoshihiro, Kawaoka" sort="Yoshihiro, Kawaoka" uniqKey="Yoshihiro K" first="Kawaoka" last="Yoshihiro">Kawaoka Yoshihiro</name>
</noRegion>
<name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002150 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002150 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:5174CC987A39013BB6ADFFBCD08CABDFC01216C1 |texte= Nucleotide sequence of the avian influenza A/Mallard/NY/6750/78 virus polymerase genes }}
This area was generated with Dilib version V0.6.33. |